Structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
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چکیده
منابع مشابه
Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions
The cytosolic tripartite NLR receptors serve as important signalling platforms in innate immunity. While the C-terminal domains act as sensor and activation modules, the N-terminal death-like domain, e.g. the CARD or pyrin domain, is thought to recruit downstream effector molecules by homotypic interactions. Such homotypic complexes have been determined for all members of the death-domain super...
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تاریخ انتشار 2014